Invited Speaker

Christine E. Brown, PhD

Professor
City of Hope
Deputy Director, T Cell Therapeutics Research Laboratory (TCTRL)
Heritage Provider, Network in Immunotherapy 

Dr. Brown provides scientific oversight for the translational research programs and ongoing clinical trials evaluating CAR T cell therapy at City of Hope. Her efforts to develop glioblastoma-targeted CAR T cells, improve T cell manufacturing, and optimize routes of T cell delivery have led to the initiation of several first-in-human clinical trials. Dr. Brown’s ongoing research efforts also aim to develop strategies to limit tumor antigen escape and to overcome the suppressive tumor microenvironment, critical challenges limiting the effectiveness of CAR T cell therapy for treatment of solid tumors. 

Dr. Brown received her doctoral degree from the University of California, Berkeley, and was a Leukemia & Lymphoma Scholar during her post-doctoral fellowship at Pennsylvania State University. Her scientific contributions in the development and optimization of tumor-specific CAR T cells for the treatment of brain tumors are supported by the California Institute for Regenerative Medicine (CIRM), National Institutes of Health, Ivy Foundation, Gateway for Cancer Research, Rising Tide and Norris Foundation. 

Selected Publications

Wang Z, et al. Cell Stem Cell.2022 
Stern L, et al, PNAS, 2022 
Wang D, et al. Cancer Discov. 2021 
Alizadeh D, et al. Cancer Discov. 2021 
Portnow J, et al. JAMA Oncol. 2020 
Wang D, et al. Sci. Transl. Med. 2020 
Zah E, et al. Nat Commun. 2020 
Alizadeh D, et al. Cancer Immunol Res. 2019 
Brown CE, et al. N Engl J Med. 2016